Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
The results suggest that the I148M/PNPLA3 (rs738409) polymorphism is associated with the presence of pCAD in T2DM patients and with some cardiometabolic parameters.
|
27615511 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
PNPLA3 I148M was genotyped in a large obese cohort, the SOS study (n = 3,473) and in the Go-DARTS (n = 15,448), a T2D case-control study.
|
22724004 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
We aimed to assess the prevalence of patatin-like phospholipase domain-containing 3 protein (PNPLA3) gene rs738409 C > G polymorphism in Brazilian individuals with type 2 diabetes and to investigate its association with liver disease severity, diabetic chronic degenerative complications, and metabolic control.
|
31377187 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials.
|
29160303 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n=1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and PNPLA3 rs738409 genotype), with advanced hepatic fibrosis/cirrhosis.
|
24978903 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
In this study, we set out to determine whether the PNPLA3 rs738409 polymorphism was associated with liver fibrosis in unselected patients with type 2 diabetes.
|
21745307 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
This study confirms that in people with type 2 diabetes, LFC is related to rs738409 polymorphism.
|
20826584 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
The development of HCC was independently associated with PNPLA3 rs738409 (OR<sub>adjusted</sub> 1.84 [95% CI 1.55-2.18], p = 1.85 × 10<sup>-12</sup>) and TM6SF2 rs58542926 (OR<sub>adjusted</sub> 1.66 [1.30-2.13], p = 5.13 × 10<sup>-05</sup>), using an additive model, and controlling the sex, age, body mass index, and type 2 diabetes mellitus; the risk associated with carriage of MBOAT7 rs641738 (OR<sub>adjusted</sub> 1.04 [0.88-1.24], p = 0.61) was not significant.
|
29535416 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
These findings provide evidence that the PNPLA3 SNP rs738409 contributes to risk for increased liver fat content in African Americans with T2DM, an effect that appears to be independent from serum lipids.
|
21665509 |
2011 |